Predictive models for IOPs measured with NCT, GAT, and ORA among patients undergoing SMILE

Tian Han; Tian Han; Tian Han; Tian Han; Wanru Shi; Wanru Shi; Wanru Shi; Wanru Shi; Yingjun Chen; Yingjun Chen; Yingjun Chen; Yingjun Chen; Yang Shen; Yang Shen; Yang Shen; Yang Shen; Ye Xu; Ye Xu; Ye Xu; Ye Xu; Xingtao Zhou; Xingtao Zhou; Xingtao Zhou; Xingtao Zhou

doi:10.3389/fbioe.2022.1030458

Frontiers in Bioengineering and Biotechnology (Dec 2022)

Predictive models for IOPs measured with NCT, GAT, and ORA among patients undergoing SMILE

Tian Han,
Tian Han,
Tian Han,
Tian Han,
Wanru Shi,
Wanru Shi,
Wanru Shi,
Wanru Shi,
Yingjun Chen,
Yingjun Chen,
Yingjun Chen,
Yingjun Chen,
Yang Shen,
Yang Shen,
Yang Shen,
Yang Shen,
Ye Xu,
Ye Xu,
Ye Xu,
Ye Xu,
Xingtao Zhou,
Xingtao Zhou,
Xingtao Zhou,
Xingtao Zhou

Affiliations

Tian Han: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Tian Han: NHC Key Laboratory of Myopia Fudan University, Shanghai, China
Tian Han: Research Center of Ophthalmology and Optometry Shanghai, Shanghai, China
Tian Han: Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
Wanru Shi: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Wanru Shi: NHC Key Laboratory of Myopia Fudan University, Shanghai, China
Wanru Shi: Research Center of Ophthalmology and Optometry Shanghai, Shanghai, China
Wanru Shi: Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
Yingjun Chen: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Yingjun Chen: NHC Key Laboratory of Myopia Fudan University, Shanghai, China
Yingjun Chen: Research Center of Ophthalmology and Optometry Shanghai, Shanghai, China
Yingjun Chen: Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
Yang Shen: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Yang Shen: NHC Key Laboratory of Myopia Fudan University, Shanghai, China
Yang Shen: Research Center of Ophthalmology and Optometry Shanghai, Shanghai, China
Yang Shen: Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
Ye Xu: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Ye Xu: NHC Key Laboratory of Myopia Fudan University, Shanghai, China
Ye Xu: Research Center of Ophthalmology and Optometry Shanghai, Shanghai, China
Ye Xu: Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China
Xingtao Zhou: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Xingtao Zhou: NHC Key Laboratory of Myopia Fudan University, Shanghai, China
Xingtao Zhou: Research Center of Ophthalmology and Optometry Shanghai, Shanghai, China
Xingtao Zhou: Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care (20DZ2255000), Shanghai, China

DOI: https://doi.org/10.3389/fbioe.2022.1030458
Journal volume & issue: Vol. 10

Abstract

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Purpose: To develop predictive models for the intraocular pressure (IOP) of patients undergoing small incision lenticule extraction (SMILE) procedures, measured with a noncontact tonometer (NCT), Goldmann applanation tonometry (GAT), and an ocular response analyzer (ORA).Methods: In this prospective study, a total of 104 eyes (−6.23 ± 2.06 diopters) of 52 patients (24.38 ± 4.76 years) undergoing SMILE procedures were included. The intraocular pressure was measured (IOPNCT with NCT, IOPGAT with GAT, and IOPcc and IOPg with ORA) before surgery and at postoperative 6 months. Information on age, preoperative and attempted spherical equivalent (SE), ablation depth, preoperative values and postoperative changes in central corneal thickness (CCT), K1, K2, Km, corneal hysteresis (CH) and corneal resistance factor (CRF) values was collected in order to predict IOPs.Results: All surgeries were uneventful. At postoperative 6 months, the efficacy and safety index were 1.04 ± 0.15 and 1.08 ± 0.18, respectively. Significant decreases were detected in postoperative IOPNCT, IOPGAT, IOPcc, and IOPg compared to preoperative values (all p < 0.001). No relationship was found between any IOP and ablation depth, attempted SE, and preoperative SE, as well as CCTdifference (all p > 0.05). Predictive models for IOPs were constructed to predict preoperative values, and R2 values were 67.5% (IOPNCT), 64.5% (IOPGAT), 78.7% (IOPcc), and 82.0% (IOPg). The prediction band of IOPNCT and IOPGAT was 7.4–15.1 mmHg and 8–16 mmHg, respectively.Conclusion: Predictive models for IOP measurements after SMILE procedures can be helpful in clinical practice.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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