Research progress on related factors of pathogenicity of urate crystals in patients with asymptomatic hyperuricemia

Abstract

Asymptomatic hyperuricemia（AH）is a common metabolic disease characterized by elevated serum concentrations of uric acid. When the serum uric acid exceeds the concentration threshold, urate crystals will crystallize and deposit in the synovium, cartilage and kidney to induce acute arthritis. Although urate crystals are the gold standard for the diagnosis of gout, not all patients with urate crystals deposition eventually develop gout. Whether urate crystal deposition will eventually cause the attack of gout depends on the joint action of multiple factors, such as urate crystal-related pathogenic genes, immune status, cartilage damage, synovial fluid environment and so on. To identify the pathogenic factors and trigger mechanism of urate crystals in the process of AH developing into gout, it can provide a basis for early screening, stratified management and individualized treatment of gout in patients with AH.

Keywords

• |urate crystals|asymptomatic hyperuricemia|pathogenicity|factors