mSystems
(Jun 2021)
Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
Chao-Yue Cui,
Qian He,
Qiu-Lin Jia,
Cang Li,
Chong Chen,
Xiao-Ting Wu,
Xiao-Jing Zhang,
Zhuo-Yu Lin,
Zi-Jian Zheng,
Xiao-Ping Liao,
Barry N. Kreiswirth,
Ya-Hong Liu,
Liang Chen,
Jian Sun
Affiliations
Chao-Yue Cui
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Qian He
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Qiu-Lin Jia
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Cang Li
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Chong Chen
ORCiD Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Xiao-Ting Wu
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Xiao-Jing Zhang
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Zhuo-Yu Lin
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Zi-Jian Zheng
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Xiao-Ping Liao
ORCiD Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Barry N. Kreiswirth
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA
Ya-Hong Liu
Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Liang Chen
ORCiD Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA
Jian Sun
ORCiD Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
DOI
https://doi.org/10.1128/mSystems.00050-21
Journal volume & issue
Vol. 6,
no. 3
Abstract
Read online
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections. However, the molecular mechanisms leading to high-level tigecycline resistance remain elusive.
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