Nature Communications (Jan 2020)

Structural insight into small molecule action on Frizzleds

  • Paweł Kozielewicz,
  • Ainoleena Turku,
  • Carl-Fredrik Bowin,
  • Julian Petersen,
  • Jana Valnohova,
  • Maria Consuelo Alonso Cañizal,
  • Yuki Ono,
  • Asuka Inoue,
  • Carsten Hoffmann,
  • Gunnar Schulte

DOI
https://doi.org/10.1038/s41467-019-14149-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1.3 as a partial agonist for FZD6 with limited subtype selectivity.