Nature Communications (Aug 2021)
Neural signatures of hyperdirect pathway activity in Parkinson’s disease
- Ashwini Oswal,
- Chunyan Cao,
- Chien-Hung Yeh,
- Wolf-Julian Neumann,
- James Gratwicke,
- Harith Akram,
- Andreas Horn,
- Dianyou Li,
- Shikun Zhan,
- Chao Zhang,
- Qiang Wang,
- Ludvic Zrinzo,
- Tom Foltynie,
- Patricia Limousin,
- Rafal Bogacz,
- Bomin Sun,
- Masud Husain,
- Peter Brown,
- Vladimir Litvak
Affiliations
- Ashwini Oswal
- MRC Brain Network Dynamics Unit, University of Oxford
- Chunyan Cao
- Department of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University
- Chien-Hung Yeh
- MRC Brain Network Dynamics Unit, University of Oxford
- Wolf-Julian Neumann
- Department of Neurology, Charité University
- James Gratwicke
- Department of Clinical and Movement Neurosciences, University College London
- Harith Akram
- Department of Clinical and Movement Neurosciences, University College London
- Andreas Horn
- Department of Neurology, Charité University
- Dianyou Li
- Department of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University
- Shikun Zhan
- Department of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University
- Chao Zhang
- Department of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University
- Qiang Wang
- Department of Neurology, Charité University
- Ludvic Zrinzo
- Department of Clinical and Movement Neurosciences, University College London
- Tom Foltynie
- Department of Clinical and Movement Neurosciences, University College London
- Patricia Limousin
- Department of Clinical and Movement Neurosciences, University College London
- Rafal Bogacz
- MRC Brain Network Dynamics Unit, University of Oxford
- Bomin Sun
- Department of Neurosurgery, Affiliated Ruijin Hospital, School of Medicine, Shanghai JiaoTong University
- Masud Husain
- Nuffield Department of Clinical Neurosciences, University of Oxford
- Peter Brown
- MRC Brain Network Dynamics Unit, University of Oxford
- Vladimir Litvak
- The Wellcome Centre for Human Neuroimaging, University College London
- DOI
- https://doi.org/10.1038/s41467-021-25366-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
In Parkinson’s disease (PD), beta frequency oscillations are synchronised across the cortico-basal-ganglia circuit. The authors show in human participants that high beta frequencies propagate from the cortex to the basal ganglia via the hyperdirect pathway, indicating a pathophysiological role for this pathway in PD.
