IL-34 a Newly Discovered Cytokine

M.L. Castellani; A. Anogeianaki; P. Felaco; E. Toniato; M.A. De Lutiis; B. Shaik; M. Fulcheri; J. Vecchiet; S. Tetè; V. Salini; T.C. Theoharides; A. Caraffa; P. Antinolfi; S. Frydas; P. Conti; C. Cuccurullo; C. Ciampoli; G. Cerulli

doi:10.1177/1721727X1000800202

European Journal of Inflammation (May 2010)

IL-34 a Newly Discovered Cytokine

M.L. Castellani,
A. Anogeianaki,
P. Felaco,
E. Toniato,
M.A. De Lutiis,
B. Shaik,
M. Fulcheri,
J. Vecchiet,
S. Tetè,
V. Salini,
T.C. Theoharides,
A. Caraffa,
P. Antinolfi,
S. Frydas,
P. Conti,
C. Cuccurullo,
C. Ciampoli,
G. Cerulli

Affiliations

M.L. Castellani
A. Anogeianaki: Department of Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece
P. Felaco: Department of Human Dynamics, University of Chieti, Italy
E. Toniato
M.A. De Lutiis: Department of Human Dynamics, University of Chieti, Italy
B. Shaik: Department of Medicine, Boston University School of Medicine, Boston, MA, USA
M. Fulcheri: Department of Clinical Psychology, University of Chieti, Italy
J. Vecchiet: Infectious Diseases Division University of Chieti, Italy
S. Tetè: School of Dentistry, University of Chieti, Italy
V. Salini: Orthopaedics Division, University of Chieti
T.C. Theoharides
A. Caraffa: Orthopaedics Division, University of Perugia, Perugia, Italy
P. Antinolfi: Orthopaedics Division, University of Perugia, Perugia, Italy
S. Frydas: Parasitology and Parasit Diseases, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece
P. Conti
C. Cuccurullo: Division of Medical Pathology, University of Chieti, Italy
C. Ciampoli: School of Dentistry, University of Chieti, Italy
G. Cerulli: Orthopaedics Division, University of Perugia, Perugia, Italy

DOI: https://doi.org/10.1177/1721727X1000800202
Journal volume & issue: Vol. 8

Abstract

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In this study we describe some biological effects of IL-34, a newly discovered cytokine. We show that Il-34 stimulates monocyte cell viability and directly modulates the number and function of monocytes and regulates myeloid cell growth and differentiation. Moreover, since IL-34 in mice is involved in osteoporosis, an antagonist of this cytokine could be beneficial for the treatment of this disease.

Published in European Journal of Inflammation

ISSN: 1721-727X (Print); 2058-7392 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.sagepub.com/home/eji

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