Molecules (Jul 2017)

Synthesis and In Vitro Antimycobacterial and Antibacterial Activity of 8-OMe Ciprofloxacin-Hydrozone/Azole Hybrids

  • Zhi Xu,
  • Shu Zhang,
  • Lian-Shun Feng,
  • Xiao-Ning Li,
  • Guo-Cheng Huang,
  • Yun Chai,
  • Zao-Sheng Lv,
  • Hui-Yuan Guo,
  • Ming-Liang Liu

DOI
https://doi.org/10.3390/molecules22071171
Journal volume & issue
Vol. 22, no. 7
p. 1171

Abstract

Read online

A series of novel 8-OMe ciprofloxacin (CPFX)-hydrazone/azole hybrids were designed, synthesized, and evaluated for their in vitro biological activities. Our results reveal that all of the hydrozone-containing hybrids (except for 7) show potency against Mycobacterium tuberculosis (MTB) H37Rv (minimum inhibitory concentration (MIC): <0.5 μM), which is better than the parent drug CPFX, and comparable to moxifloxacin and isoniazid, some of the tested Gram-positive strains (MIC: 0.06–4 μg/mL), and most Gram-negative strains (MIC: ≤0.03–4 μg/mL).

Keywords