Nature Communications (Jun 2021)
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
- Burhan Uyanik,
- Anastasia R. Goloudina,
- Aamir Akbarali,
- Bogdan B. Grigorash,
- Alexey V. Petukhov,
- Sunil Singhal,
- Evgeniy Eruslanov,
- Jeanne Chaloyard,
- Lisa Lagorgette,
- Tarik Hadi,
- Ekaterina V. Baidyuk,
- Hiroyasu Sakai,
- Lino Tessarollo,
- Bernhard Ryffel,
- Sharlyn J. Mazur,
- Frederic Lirussi,
- Carmen Garrido,
- Ettore Appella,
- Oleg N. Demidov
Affiliations
- Burhan Uyanik
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Anastasia R. Goloudina
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Aamir Akbarali
- Laboratory of Cell Biology, Center for Center Research, National Cancer Institute
- Bogdan B. Grigorash
- Institute of Cytology, RAS
- Alexey V. Petukhov
- NTU Sirius
- Sunil Singhal
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Evgeniy Eruslanov
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Jeanne Chaloyard
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Lisa Lagorgette
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Tarik Hadi
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Ekaterina V. Baidyuk
- Institute of Cytology, RAS
- Hiroyasu Sakai
- Laboratory of Cell Biology, Center for Center Research, National Cancer Institute
- Lino Tessarollo
- Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute
- Bernhard Ryffel
- INEM, Experimental and Molecular Immunology and Neurogenetics, University of Orléans, CNRS, UMRP735
- Sharlyn J. Mazur
- Laboratory of Cell Biology, Center for Center Research, National Cancer Institute
- Frederic Lirussi
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Carmen Garrido
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- Ettore Appella
- Laboratory of Cell Biology, Center for Center Research, National Cancer Institute
- Oleg N. Demidov
- INSERM UMR1231, LipSTIC, University of Burgundy Franche-Comté
- DOI
- https://doi.org/10.1038/s41467-021-23330-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune responses, reducing tumor growth in preclinical cancer models.
