Vestnik Transplantologii i Iskusstvennyh Organov (Dec 2011)

ALLOTRANSPLANTATION OF MACROENCAPSULATED PARATHYROID CELLS IN SEVERE POSTSURGICAL HYPOPARATHYROIDISM: A CASE REPORT

  • V. Ja. Khryshchanovich,
  • S. I. Tretyak,
  • A. N. Kharlamova,
  • T. V. Mochort,
  • E. V. Bogomazova,
  • E. I. Kuzmenkova,
  • V. A. Kondratovich,
  • A. M. Pisarenko,
  • A. V. Romanovich

DOI
https://doi.org/10.15825/1995-1191-2011-4-60-65
Journal volume & issue
Vol. 13, no. 4
pp. 60 – 65

Abstract

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The last therapeutic alternative in severe postsurgical hypoparathyroidism is allotransplantation of macroen- capsulated parathyroid cells. With this technique, it is possible to implant cells or tissue of parathyroid origin to replace them in such patients, without immusupression. We report an allotransplant of parathyroid cells in a patient with continous endovenous requirement of calcium to survive. The macroencapsulation was carried out with a polyvinylidine difluoride (PVDF). We implant ~100 000 parathyroid cells in the deep femoral artery. In this article, we show functionality of the graft for at least 3 months without requirement of endovenous calcium. We report this procedure as a therapeutical alternative in severe hypoparathyroidism.

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