Frontiers in Human Neuroscience (Oct 2022)
Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory
- Qiang Hua,
- Qiang Hua,
- Qiang Hua,
- Qiang Hua,
- Yuanyuan Zhang,
- Yuanyuan Zhang,
- Yuanyuan Zhang,
- Qianqian Li,
- Qianqian Li,
- Qianqian Li,
- Xiaoran Gao,
- Xiaoran Gao,
- Xiaoran Gao,
- Rongrong Du,
- Rongrong Du,
- Rongrong Du,
- Yingru Wang,
- Yingru Wang,
- Yingru Wang,
- Qian Zhou,
- Qian Zhou,
- Qian Zhou,
- Ting Zhang,
- Ting Zhang,
- Ting Zhang,
- Jinmei Sun,
- Jinmei Sun,
- Jinmei Sun,
- Lei Zhang,
- Lei Zhang,
- Lei Zhang,
- Lei Zhang,
- Gong-jun Ji,
- Gong-jun Ji,
- Gong-jun Ji,
- Gong-jun Ji,
- Kai Wang,
- Kai Wang,
- Kai Wang,
- Kai Wang,
- Kai Wang,
- Kai Wang
Affiliations
- Qiang Hua
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Qiang Hua
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Qiang Hua
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Qiang Hua
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Yuanyuan Zhang
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Yuanyuan Zhang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yuanyuan Zhang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Qianqian Li
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Qianqian Li
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Qianqian Li
- Department of Psychiatry, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Xiaoran Gao
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Xiaoran Gao
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Xiaoran Gao
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Rongrong Du
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Rongrong Du
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Rongrong Du
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Yingru Wang
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Yingru Wang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yingru Wang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Qian Zhou
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Qian Zhou
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Qian Zhou
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Ting Zhang
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Ting Zhang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Ting Zhang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Jinmei Sun
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Jinmei Sun
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Jinmei Sun
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Lei Zhang
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Lei Zhang
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Lei Zhang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Lei Zhang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Gong-jun Ji
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Gong-jun Ji
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Gong-jun Ji
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Gong-jun Ji
- Hefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, China
- Kai Wang
- Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Kai Wang
- School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China
- Kai Wang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Kai Wang
- Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China
- Kai Wang
- Hefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, China
- Kai Wang
- Anhui Institute of Translational Medicine, Hefei, China
- DOI
- https://doi.org/10.3389/fnhum.2022.973298
- Journal volume & issue
-
Vol. 16
Abstract
ObjectivesSeveral studies have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on associative memory (AM) but findings were inconsistent. Here, we aimed to test whether twice-daily rTMS could significantly improve AM.MethodsIn this single-blind, sham-controlled experiment, 40 participants were randomized to receive twice-daily sham or real rTMS sessions for five consecutive days (a total of 16,000 pulses). The stimulation target in left inferior parietal lobule (IPL) exhibiting peak functional connectivity to the left hippocampus was individually defined for each participant. Participants completed both a picture-cued word association task and Stroop test at baseline and 1 day after the final real or sham rTMS session. Effects of twice-daily rTMS on AM and Stroop test performance were compared using two-way repeated measures analysis of variance with main factors Group (real vs. sham) and Time (baseline vs. post-rTMS).ResultsThere was a significant Group × Time interaction effect. AM score was significantly enhanced in the twice-daily real group after rTMS, but this difference could not survive the post hoc analysis after multiple comparison correction. Further, AM improvement in the twice-daily real group was not superior to a previously reported once-daily rTMS group receiving 8,000 pulses. Then, we combined the twice- and once-daily real groups, and found a significant Group × Time interaction effect. Post hoc analysis indicated that the AM score was significantly enhanced in the real group after multiple comparisons correction.ConclusionOur prospective experiment did not show significant rTMS effect on AM, but this effect may become significant if more participants could be recruited as revealed by our retrospective analysis.
Keywords
- associative memory
- hippocampal-cortical network
- inferior parietal lobule
- stimulation dose
- transcranial magnetic stimulation
