Nature Communications (Dec 2018)
GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis
- Otavio Cabral-Marques,
- Alexandre Marques,
- Lasse Melvær Giil,
- Roberta De Vito,
- Judith Rademacher,
- Jeannine Günther,
- Tanja Lange,
- Jens Y. Humrich,
- Sebastian Klapa,
- Susanne Schinke,
- Lena F. Schimke,
- Gabriele Marschner,
- Silke Pitann,
- Sabine Adler,
- Ralf Dechend,
- Dominik N. Müller,
- Ioana Braicu,
- Jalid Sehouli,
- Kai Schulze-Forster,
- Tobias Trippel,
- Carmen Scheibenbogen,
- Annetine Staff,
- Peter R. Mertens,
- Madlen Löbel,
- Justin Mastroianni,
- Corinna Plattfaut,
- Frank Gieseler,
- Duska Dragun,
- Barbara Elizabeth Engelhardt,
- Maria J. Fernandez-Cabezudo,
- Hans D. Ochs,
- Basel K. al-Ramadi,
- Peter Lamprecht,
- Antje Mueller,
- Harald Heidecke,
- Gabriela Riemekasten
Affiliations
- Otavio Cabral-Marques
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Alexandre Marques
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Lasse Melvær Giil
- Deaconess Hospital, University of Bergen
- Roberta De Vito
- Department of Computer Science, Princeton University
- Judith Rademacher
- Department of Gastroenterology, Infectiology and Rheumatology, Charité University Hospital
- Jeannine Günther
- Dept. of Rheumatology and Clinical Immunology, Charité University Hospital
- Tanja Lange
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Jens Y. Humrich
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Sebastian Klapa
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Susanne Schinke
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Lena F. Schimke
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Gabriele Marschner
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Silke Pitann
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Sabine Adler
- University Hospital and University of Bern
- Ralf Dechend
- Experimental and Clinical Research Center, a collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin
- Dominik N. Müller
- Experimental and Clinical Research Center, a collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin
- Ioana Braicu
- Department of Nephrology and Cardiovascular Research, Campus Virchow, Charité University Hospital
- Jalid Sehouli
- Department of Gynecology, Charité University Hospital, Berlin and Tumor Bank Ovarian Cancer Network (TOC)
- Kai Schulze-Forster
- Department of Urology, Charité University Hospital
- Tobias Trippel
- Dept. of Internal Medicine & Cardiology, Charité University Hospital
- Carmen Scheibenbogen
- Institute for Medical Immunology, Charité University Hospital Berlin
- Annetine Staff
- University of Oslo and Oslo University Hospital
- Peter R. Mertens
- University Clinic for Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University Magdeburg
- Madlen Löbel
- Institute for Medical Immunology, Charité University Hospital Berlin
- Justin Mastroianni
- Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert Ludwigs University (ALU) of Freiburg
- Corinna Plattfaut
- Section Experimental Oncology, University Hospital and Medical School (UKSH), University of Lübeck
- Frank Gieseler
- Section Experimental Oncology, University Hospital and Medical School (UKSH), University of Lübeck
- Duska Dragun
- Department of Nephrology and Cardiovascular Research, Campus Virchow, Charité University Hospital
- Barbara Elizabeth Engelhardt
- Department of Computer Science, Princeton University
- Maria J. Fernandez-Cabezudo
- Department of Biochemistry College of Medicine and Health Sciences, UAE University
- Hans D. Ochs
- Department of Pediatrics, University of Washington School of Medicine, Seattle Children’s Research Institute
- Basel K. al-Ramadi
- Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, UAE University
- Peter Lamprecht
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Antje Mueller
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Harald Heidecke
- Department of Urology, Charité University Hospital
- Gabriela Riemekasten
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- DOI
- https://doi.org/10.1038/s41467-018-07598-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological function in maintaining immune homeostasis.
