Advances in Radiation Oncology (Dec 2024)

The Fletcher-Cox Pathway: A Unique View on Clinical Trial Education

  • Shalini Moningi, MD,
  • Shane Stecklein, MD, PhD,
  • Sonal Noticewala, MD, MAS,
  • Olsi Gjyshi, MD,
  • Todd Pezzi, MD,
  • David Boyce-Fappiano, MD,
  • Prajnan Das, MD, MS, MPH,
  • Bruce Minsky, MD,
  • Emma B. Holliday, MD,
  • Andrew J. Bishop, MD,
  • Albert C. Koong, MD, PhD,
  • Chelsea C. Pinnix, MD, PhD

Journal volume & issue
Vol. 9, no. 12
p. 101637

Abstract

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Purpose: There currently are no established formal mentorship and training programs for radiation oncology (RO) trainees to learn trial design, creation, writing, or implementation. There only exists informal training on analyzing clinical trials in RO residency programs. The integration of a longitudinal formal training and mentorship program for clinical trialists—consisting of clinical trial education, design, mentorship, and implementation during the RO residency education—will give residents not only formal teaching in the subject but also strong tools and requisite mentorship in hopes to help them succeed as future academic physicians and leaders in the field of RO. Methods and Materials: We developed a clinical trial training pathway in 2018 at MD Anderson Cancer Center, proposing it as a pilot program. The “Fletcher-Cox Pathway” was accepted with a highly positive response by trainees and is now offered as a standard option to RO trainees at our institution. Results: With the guidance of their principal investigator, residents participating in this pathway design and submit a clinical trial for institutional review board review. In 2019, after implementation of the pilot program, 4 of the incoming 7 residents joined the pathway. The program continues, and the current cohort of trainees have received training in clinical trial design and worked with dedicated mentor(s) regarding clinical trial ideas; their studies are currently accruing patients. Conclusions: This pilot program has been viewed by trainees and mentors as successful; it highlights how a structured approach meets a clear need within RO training. We envision the creation of a national platform to increase access, whereby programs adopt this clinical trialist educational pathway, which ultimately leads to the development of a robust clinical trial community with communal resources. We hope that this not only improves and provides educational initiatives to all trainees but also initiates further collaboration.