Metagenomic mining and structure-function studies of a hyper-thermostable cellobiohydrolase from hot spring sediment

Migiwa Takeda; Seiki Baba; Jiro Okuma; Yoshitsugu Hirose; Asuka Nishimura; Masaki Takata; Kohei Oda; Daisuke Shibata; Takashi Kumasaka; Yasuhiro Kondo

doi:10.1038/s42003-022-03195-1

Communications Biology (Mar 2022)

Metagenomic mining and structure-function studies of a hyper-thermostable cellobiohydrolase from hot spring sediment

Migiwa Takeda,
Seiki Baba,
Jiro Okuma,
Yoshitsugu Hirose,
Asuka Nishimura,
Masaki Takata,
Kohei Oda,
Daisuke Shibata,
Takashi Kumasaka,
Yasuhiro Kondo

Affiliations

Migiwa Takeda: Honda Research Institute Japan Co. Ltd., Kazusa Incubation Center
Seiki Baba: Japan Synchrotron Radiation Research Institute (JASRI), SPring-8
Jiro Okuma: Honda Research Institute Japan Co. Ltd., Kazusa Incubation Center
Yoshitsugu Hirose: Honda Research Institute Japan Co. Ltd., Kazusa Incubation Center
Asuka Nishimura: Honda Research Institute Japan Co. Ltd., Kazusa Incubation Center
Masaki Takata: Japan Synchrotron Radiation Research Institute (JASRI), SPring-8
Kohei Oda: Honda Research Institute Japan Co. Ltd., Kazusa Incubation Center
Daisuke Shibata: Kazusa DNA Research Institute
Takashi Kumasaka: Japan Synchrotron Radiation Research Institute (JASRI), SPring-8
Yasuhiro Kondo: Honda Research Institute Japan Co. Ltd., Kazusa Incubation Center

DOI: https://doi.org/10.1038/s42003-022-03195-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Bacteria from hot springs are known for highly thermostable enzymes, which may have industrial potential. Here, a unique thermostable cellobiohydrolase is reported that can breakdown cellulose at temperature up to 95 degrees Celsius.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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