Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses

Woongchang Yoon; Soohong Min; Ho-Sung Ryu; Sun Ju Chung; Jongkyeong Chung

doi:10.1038/s42003-022-03830-x

Communications Biology (Aug 2022)

Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses

Woongchang Yoon,
Soohong Min,
Ho-Sung Ryu,
Sun Ju Chung,
Jongkyeong Chung

Affiliations

Woongchang Yoon: School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University
Soohong Min: School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University
Ho-Sung Ryu: Department of Neurology, Kyungpook National University Hospital
Sun Ju Chung: Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine
Jongkyeong Chung: School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University

DOI: https://doi.org/10.1038/s42003-022-03830-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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A combined research approach using GWAS on Parkinson's disease patients and a Drosophila model of L-DOPA-induced dyskinesia (LID) reveals that LID is linked to ADCY2 signaling.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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