<b>A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1<i>H</i>)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents</b>

Abstract

A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K2CO3 is achieved in good yields.

Keywords

• 3-Cyano-2(1<i>H</i>)-pyridinones
• 2-Imino
• Cardiotonic
• Dimethoxyacetophenone