Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome

Chi Yao; Yuwei Xu; Jianpu Tang; Pin Hu; Hedong Qi; Dayong Yang

doi:10.1038/s41467-022-35472-2

Nature Communications (Dec 2022)

Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome

Chi Yao,
Yuwei Xu,
Jianpu Tang,
Pin Hu,
Hedong Qi,
Dayong Yang

Affiliations

Chi Yao: Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University
Yuwei Xu: Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University
Jianpu Tang: Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University
Pin Hu: Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University
Hedong Qi: Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University
Dayong Yang: Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University

DOI: https://doi.org/10.1038/s41467-022-35472-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Artificial organelles can potentially be used support cellular functions, but there is a trade-off between cellular uptake and cellular retention. Here, the authors report the dynamic assembly of DNA-ceria-based artificial peroxisomes in cells, and show they can be used to reduce intracellular ROS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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