Nature Communications (Oct 2018)
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Abstract
Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.