Nature Communications (Oct 2018)

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

  • Jacob Lauwring Andersen,
  • Borbala Gesser,
  • Erik Daa Funder,
  • Christine Juul Fælled Nielsen,
  • Helle Gotfred-Rasmussen,
  • Mads Kirchheiner Rasmussen,
  • Rachel Toth,
  • Kurt Vesterager Gothelf,
  • J. Simon C. Arthur,
  • Lars Iversen,
  • Poul Nissen

DOI
https://doi.org/10.1038/s41467-018-06787-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.