Cancers (Dec 2021)

Therapeutic Targets in Diffuse Midline Gliomas—An Emerging Landscape

  • Elisha Hayden,
  • Holly Holliday,
  • Rebecca Lehmann,
  • Aaminah Khan,
  • Maria Tsoli,
  • Benjamin S. Rayner,
  • David S. Ziegler

DOI
https://doi.org/10.3390/cancers13246251
Journal volume & issue
Vol. 13, no. 24
p. 6251

Abstract

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Diffuse midline gliomas (DMGs) are invariably fatal pediatric brain tumours that are inherently resistant to conventional therapy. In recent years our understanding of the underlying molecular mechanisms of DMG tumorigenicity has resulted in the identification of novel targets and the development of a range of potential therapies, with multiple agents now being progressed to clinical translation to test their therapeutic efficacy. Here, we provide an overview of the current therapies aimed at epigenetic and mutational drivers, cellular pathway aberrations and tumor microenvironment mechanisms in DMGs in order to aid therapy development and facilitate a holistic approach to patient treatment.

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