Nature Communications (Jun 2016)
MTHFD1 controls DNA methylation in Arabidopsis
- Martin Groth,
- Guillaume Moissiard,
- Markus Wirtz,
- Haifeng Wang,
- Carolina Garcia-Salinas,
- Perla A. Ramos-Parra,
- Sylvain Bischof,
- Suhua Feng,
- Shawn J. Cokus,
- Amala John,
- Danielle C. Smith,
- Jixian Zhai,
- Christopher J. Hale,
- Jeff A. Long,
- Ruediger Hell,
- Rocío I. Díaz de la Garza,
- Steven E. Jacobsen
Affiliations
- Martin Groth
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Guillaume Moissiard
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Markus Wirtz
- Centre for Organismal Studies, University of Heidelberg
- Haifeng Wang
- Basic Forestry and Proteomics Research Center, Haixia Institute of Science and Technology (HIST), Fujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University
- Carolina Garcia-Salinas
- Tecnologico de Monterrey, Campus Monterrey
- Perla A. Ramos-Parra
- Tecnologico de Monterrey, Campus Monterrey
- Sylvain Bischof
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Suhua Feng
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Shawn J. Cokus
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Amala John
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Danielle C. Smith
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Jixian Zhai
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Christopher J. Hale
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Jeff A. Long
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- Ruediger Hell
- Centre for Organismal Studies, University of Heidelberg
- Rocío I. Díaz de la Garza
- Tecnologico de Monterrey, Campus Monterrey
- Steven E. Jacobsen
- Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles
- DOI
- https://doi.org/10.1038/ncomms11640
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
DNA methylation contributes to transcriptional silencing. Here, Groth et al.show that mutant plants defective in MTHFD1, an enzyme involved in folate metabolism, have a DNA hypomethylation phenotype highlighting the link between one-carbon metabolism and DNA methylation, which is mediated by SAM as a common methyl donor.
