ABCD: Arquivos Brasileiros de Cirurgia Digestiva (Dec 2024)

LIVING DONOR LIVER TRANSPLANT FOR INTRAHEPATIC CHOLANGIOCARCINOMA. AN INITIAL BRAZILIAN EXPERIENCE

  • Eduardo de Souza Martins FERNANDES,
  • Felipe Pedreira Tavares de MELLO,
  • Ronaldo de Oliveira ANDRADE,
  • Camila Liberato GIRÃO,
  • Camila CESAR,
  • Leandro Savattone PIMENTEL,
  • Henrique Sergio Moraes COELHO,
  • Samanta Teixeira BASTO,
  • Munique SIQUEIRA,
  • Anderson BRITO,
  • Claudia Cristina TAVARES DE SOUSA,
  • Tercio GENZINI,
  • Orlando Jorge Martins TORRES

DOI
https://doi.org/10.1590/0102-6720202400045e1839
Journal volume & issue
Vol. 37

Abstract

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ABSTRACT BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) was considered a contraindication for liver transplantation. However, recent studies have shown that highly selected cases of patients with a good response to neoadjuvant therapy may achieve acceptable survival rates when following liver transplantation. AIMS: To present two cases of patients with iCCA, without extrahepatic disease, who underwent living donor liver transplantation after receiving neoadjuvant chemotherapy. METHODS: Two cases of patients with histopathological diagnosis of locally advanced iCCA, ineligible for resection and without evidence of extrahepatic disease, are presented. RESULTS: These patients underwent at least nine sessions of neoadjuvant chemotherapy, including Gemcitabine and Cisplatin, with or without the addition of immunobiological agents, resulting in a radiological tumor response. They subsequently underwent living donor liver transplantation. The average follow-up time was 15 months, with no clinical or radiological signs of disease. CONCLUSIONS: In well-selected patients without extrahepatic disease, living donor liver transplantation represents a potential therapeutic option for iCCA.

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