Research progress on the relationship between neutrophil extracellular traps and liver cancer

Abstract

Neutrophil extracellular traps （NET） are reticular structures composed of depolymerized chromatin and granule proteins. The formation process of NET refers to neutrophil inflammatory apoptosis （NETosis）， which is thought to be excreted from dying neutrophils to capture and kill pathogenic microorganisms. NET is closely related to many malignant tumors such as liver cancer， gastric cancer， intestinal cancer and lung cancer. In recent years， more and more studies have shown that NET exists in both cancer patients and animal models. NET promotes tumor growth， invasion， metastasis and cancer-related thrombosis. Blocking or disrupting the formation of NET can inhibit tumor progression and cancer-related thrombosis. Therefore， targeting NET may be a new anti-tumor therapy. In this article， the formation mechanism of NET and its role in liver cancer were reviewed， and the role of NET in the pathogenesis of liver cancer was deeply analyzed， aiming to provide new ideas and treatment methods for liver cancer.

Keywords

• |neutrophil extracellular traps|liver cancer|therapeutic target