Thermodynamic phase plane analysis of ventricular contraction and relaxation

Abstract

Abstract Background Ventricular function has conventionally been characterized using indexes of systolic (contractile) or diastolic (relaxation/stiffness) function. Systolic indexes include maximum elastance or equivalently the end-systolic pressure volume relation and left ventricular ejection fraction. Diastolic indexes include the time constant of isovolumic relaxation – and the end-diastolic pressure-volume relation. Conceptualization of ventricular contraction/relaxation coupling presents a challenge when mechanical events of the cardiac cycle are depicted in conventional pressure, P, or volume, V, terms. Additional conceptual difficulty arises when ventricular/vascular coupling is considered using P, V variables. Methods We introduce the concept of thermodynamic phase-plane, TPP, defined by the PdV and VdP axes. Results TPP allows all cardiac mechanical events and their coupling to the vasculature to be geometrically depicted and simultaneously analyzed. Conclusion Conventional systolic and diastolic function indexes are easily recovered and novel indexes of contraction-relaxation coupling are discernible.

Keywords

• Ventricular function
• diastolic function
• pressure-volume loops
• contraction/relaxation coupling.