Journal of Inflammation Research (Jun 2025)

Predictive Potential of CRTP5 and SII for Coronary Artery Severity and Myocardial Fibrosis in Patients with NSTE-ACS: An Exploratory Biomarker Study

  • Ji J,
  • Qiao M,
  • Ding Y,
  • Wei X,
  • Wan D,
  • Wu L,
  • Liu H

Journal volume & issue
Vol. Volume 18, no. Issue 1
pp. 7127 – 7138

Abstract

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Jinrui Ji,1,2,&ast; Mu Qiao,3,4,&ast; Ya’nan Ding,1,2,&ast; Xiaoyun Wei,1,2,&ast; Dongyu Wan,1,2,&ast; Lei Wu,1,2,&ast; Hengliang Liu1,2,&ast; 1Clinical Medical Department, Faculty of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 2Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, 450000, People’s Republic of China; 4Department of Cardiology, Zhengzhou Cardiovascular Institute, Zhengzhou, 450000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hengliang Liu, Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China, Email [email protected]: Findings from this research aim to enhance clinical assessments of coronary artery disease severity and myocardial fibrosis (MF).Methods: A total of 523 eligible non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients were included. Clinical data were collected and analyzed. Multifactorial logistic regression analysis was applied to identify factors influencing coronary artery lesions in patients with NSTE-ACS. Diagnostic accuracy for Complement C1q tumor necrosis factor-related protein 5 (CTRP5) and systemic immune-inflammation index (SII) in assessing coronary artery lesions and MF was analyzed via receiver operating characteristic (ROC) curve analysis.Results: The levels of CTRP5 and SII were significantly different between the unstable angina pectoris (UAP) and ST-segment elevation myocardial infarction (NSTEMI) groups (all P< 0.05). Significant differences in CTRP5, SII, PCI, and PCIII were noted across the Single-, Two-, and Three-vessel lesion groups (all P< 0.05). Multifactorial logistic regression analysis revealed that CTRP5 (odds ratio [OR], 1.621; 95% confidence interval [CI], 1.103– 1.984; P< 0.001) and SII (OR, 1.473; 95% CI, 1.178– 1.840; P< 0.001) were independent risk factors for three-vessel lesions. The ROC curve analysis demonstrated that CTRP5 and SII effectively predicted three-vessel lesions, with area under curve (AUC) values of 0.823 [cut-off value13.99; 95% confidence interval (CI), 0.779– 0.866, P< 0.001] and 0.796 [cut-off value, 837.5; 95% CI, 0.747– 0.845, P< 0.001], respectively. The ROC curve analysis evaluated the ability of CTRP5 and SII to predict MF; AUC values were 0.809 (cut-off value, 11.95; 95% CI, 0.724– 0.895, P< 0.001) and 0.713 (cut-off value, 624.2; 95% CI, 0.611– 0.815, P< 0.001), respectively.Conclusion: CTRP5 and SII demonstrate strong potential as early diagnostic markers for assessing the severity of coronary artery disease and MF in patients with NSTE-ACS.Keywords: complement C1q tumor necrosis factor-related protein 5, systemic immune-inflammation index, myocardial fibrosis, non-ST-segment elevation acute coronary syndromes

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