ASK1 signalling regulates brown and beige adipocyte function

Kazuki Hattori; Isao Naguro; Kohki Okabe; Takashi Funatsu; Shotaro Furutani; Kohsuke Takeda; Hidenori Ichijo

doi:10.1038/ncomms11158

Nature Communications (Apr 2016)

ASK1 signalling regulates brown and beige adipocyte function

Kazuki Hattori,
Isao Naguro,
Kohki Okabe,
Takashi Funatsu,
Shotaro Furutani,
Kohsuke Takeda,
Hidenori Ichijo

Affiliations

Kazuki Hattori: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Isao Naguro: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kohki Okabe: The laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Takashi Funatsu: The laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Shotaro Furutani: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kohsuke Takeda: Division of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University
Hidenori Ichijo: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms11158
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The protein kinase ASK1 has been linked to cellular stress responses. Here the authors show that ASK1 also regulates gene expression and activity of beige and brown adipocytes, and demonstrate adipocyte ASK1 has a physiological role in regulating thermogenesis in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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