Nature Communications (Apr 2016)

ASK1 signalling regulates brown and beige adipocyte function

  • Kazuki Hattori,
  • Isao Naguro,
  • Kohki Okabe,
  • Takashi Funatsu,
  • Shotaro Furutani,
  • Kohsuke Takeda,
  • Hidenori Ichijo

Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10


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The protein kinase ASK1 has been linked to cellular stress responses. Here the authors show that ASK1 also regulates gene expression and activity of beige and brown adipocytes, and demonstrate adipocyte ASK1 has a physiological role in regulating thermogenesis in mice.