Applied Sciences (Jul 2021)

Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia

  • Mohamed F. Sanad,
  • Bianca P. Meneses-Brassea,
  • Dawn S. Blazer,
  • Shirin Pourmiri,
  • George C. Hadjipanayis,
  • Ahmed A. El-Gendy

DOI
https://doi.org/10.3390/app11146637
Journal volume & issue
Vol. 11, no. 14
p. 6637

Abstract

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Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperature. We found that the as-synthesized core shells assembled with spherical morphology, including face-centered-cubic Fe cores coated and Au shells. The high-resolution transmission microscope images (HRTEM) revealed the formation of Fe/Au core/shell nanoparticles. The magnetic properties of the samples showed hysteresis loops with coercivity (HC) close to zero, revealing superparamagnetic-like behavior at room temperature. The saturation magnetization (MS) has the value of 165 emu/g for the as-synthesized sample with a Fe:Au ratio of 2:1. We also studied the feasibility of those core-shell particles for magnetic hyperthermia using different frequencies and different applied alternating magnetic fields. The Fe/Au core-shell nanoparticles achieved a specific absorption rate of 50 W/g under applied alternating magnetic field with amplitude 400 Oe and 304 kHz frequency. Based on our findings, the samples can be used as a promising candidate for magnetic hyperthermia for cancer therapy.

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