APPLICATION OF PHOTODYNAMIC THERAPY IN TREATMENT OF MALIGNANT NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM
A.A. SUFIANOV,
D.A. MURZAEVA,
I.S. SHELYAGIN,
R.A. SUFIANOV
Affiliations
A.A. SUFIANOV
Department of Neurosurgery, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation. Federal Center for Neurosurgery, Tyumen, Russian Federation
D.A. MURZAEVA
Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
I.S. SHELYAGIN
Department of Neurosurgery, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation. Federal Center for Neurosurgery, Tyumen, Russian Federation
R.A. SUFIANOV
Department of Neurosurgery, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
World literature data dedicated to the problem of application of photodynamic therapy (PDT) in the neurooncology has been studied and analyzed, and also the prospects for development and improvement of surgical treatment for malignant neoplasms of CNS are covered. The following databases are used: PubMed, Web of Science, Scopus, MEDLINE, EMBASE, Biosis Citation Index, SciELO Citation Index, RSCI. Noted, that PDT treatment of tumors can be widely used in various areas of oncology demonstrating high efficiency and radical value. In particular, the method shows good treatment results for brain glioblastomas. At the same time, the use of modern photosensitizers and methods of delivering pharmaceutical drugs to affected cells in conjunction with the use of fiber optics makes it possible to minimize damage to surrounding tissues and possible neurological deficits.
