MHC-I genotype drives early immune selection of oncogenic mutations

Abstract

MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.

Keywords

• antigen presentation
• cancer predisposition
• cancer susceptibility prediction
• cancer
• human leukocyte antigen
• immunology, immunoediting
• immunotherapy
• major histocompatibility complex
• neoantigens