Pulmonary Fissure Segmentation in CT Images Using Image Filtering and Machine Learning

Abstract

Background: Both lung lobe segmentation and lung fissure segmentation are useful in the clinical diagnosis and evaluation of lung disease. It is often of clinical interest to quantify each lobe separately because many diseases are associated with specific lobes. Fissure segmentation is important for a significant proportion of lung lobe segmentation methods, as well as for assessing fissure completeness, since there is an increasing requirement for the quantification of fissure integrity. Methods: We propose a method for the fully automatic segmentation of pulmonary fissures on lung computed tomography (CT) based on U-Net and PAN models using a Derivative of Stick (DoS) filter for data preprocessing. Model ensembling is also used to improve prediction accuracy. Results: Our method achieved an F1 score of 0.916 for right-lung fissures and 0.933 for left-lung fissures, which are significantly higher than the standalone DoS results (0.724 and 0.666, respectively). We also performed lung lobe segmentation using fissure segmentation. The lobe segmentation algorithm shows results close to those of state-of-the-art methods, with an average Dice score of 0.989. Conclusions: The proposed method segments pulmonary fissures efficiently and have low memory requirements, which makes it suitable for further research in this field involving rapid experimentation.

Keywords

• lung
• fissure
• segmentation
• computed tomography
• machine learning
• CNN