Nature Communications (Nov 2022)
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment
- Roberta Piras,
- Emily Y. Ko,
- Connor Barrett,
- Marco De Simone,
- Xianzhi Lin,
- Marina T. Broz,
- Fernando H. G. Tessaro,
- Mireia Castillo-Martin,
- Carlos Cordon-Cardo,
- Helen S. Goodridge,
- Dolores Di Vizio,
- Mona Batish,
- Kate Lawrenson,
- Y. Grace Chen,
- Keith Syson Chan,
- Jlenia Guarnerio
Affiliations
- Roberta Piras
- Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Emily Y. Ko
- Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Connor Barrett
- Department of Medical and Molecular Sciences, University of Delaware
- Marco De Simone
- Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Xianzhi Lin
- Women’s Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Marina T. Broz
- Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Fernando H. G. Tessaro
- Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Mireia Castillo-Martin
- Department of Pathology, Mount Sinai School of Medicine, The Mount Sinai Medical Center
- Carlos Cordon-Cardo
- Department of Pathology, Mount Sinai School of Medicine, The Mount Sinai Medical Center
- Helen S. Goodridge
- Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center
- Dolores Di Vizio
- Department of Surgery and Department of Pathology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Mona Batish
- Department of Medical and Molecular Sciences, University of Delaware
- Kate Lawrenson
- Women’s Cancer Research Program at Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Y. Grace Chen
- Department of Immunobiology, Yale University School of Medicine
- Keith Syson Chan
- Department of Pathology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Jlenia Guarnerio
- Department of Radiation Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-34872-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Circular RNAs can contribute to tumour progression. Here the authors show that two circular RNAs, circCsnk1g3 and circAnkib1 promote sarcoma growth by controlling the expression of interferon related genes and pro-inflammatory factors in sarcoma cells
