Cell Death Discovery (Aug 2021)

Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

  • Yan Liu,
  • Qiuyun Chen,
  • Yanan Zhu,
  • Tiying Wang,
  • Lijuan Ye,
  • Hei Han,
  • Zhihong Yao,
  • Zuozhang Yang

DOI
https://doi.org/10.1038/s41420-021-00596-9
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Abstract Distant metastasis is the main cause of death for cancer patients. Recently, the newly discovered programmed cell death includes necroptosis, pyroptosis, and ferroptosis, which possesses an important role in the process of tumor metastasis. At the same time, it is widely reported that non-coding RNA precisely regulates programmed death and tumor metastasis. In the present review, we summarize the function and role of necroptosis, pyrolysis, and ferroptosis involving in cancer metastasis, as well as the regulatory factors, including non-coding RNAs, of necroptosis, pyroptosis, and ferroptosis in the process of tumor metastasis.