Effects of perinatal complications on coagulation function in pregnant women

Abstract

Objectives: To investigate the effects of various complications on the coagulation function of perinatal women. Methods: A total of 210 pregnant women between November 2016 and June 2017 were recruited. The coagulation function indexes, including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and thrombin time (TT), were evaluated in pregnant women with group B Streptococcus (GBS), positive nonstress test (NST), scarred uterus, prenatal fever, macrosomia, gestational hypertension, gestational diabetes, premature rupture of membranes (PROMs), threatened abortion, and oligohydramnios. Results: No significant differences were found in PT, APTT, FIB, and TT in pregnant women with GBS, positive NST, scarred uterus, macrosomia, gestational hypertension, gestational diabetes, PROMs, and oligohydramnios. Moreover, significantly decreased PT and APTT and significantly increased TT were found in pregnant women with prenatal fever compared to normal controls, whereas significantly increased TT was also observed in those with threatened abortion. Conclusions: Among the complications that occur in pregnant women, prenatal fever and threatened abortion have important effects on coagulation function.

Keywords

• Coagulation; Complication; Perinatal Period; Pregnancy; Prenatal Fever; Threatened Abortion