Nature Communications (Nov 2022)

Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub

  • Wei Tan,
  • Sihua Cheng,
  • Yingying Li,
  • Xiao-Yang Li,
  • Ning Lu,
  • Jingxian Sun,
  • Guiyue Tang,
  • Yujiao Yang,
  • Kezhu Cai,
  • Xuefei Li,
  • Xijun Ou,
  • Xiang Gao,
  • Guo-Ping Zhao,
  • W. Seth Childers,
  • Wei Zhao

DOI
https://doi.org/10.1038/s41467-022-35000-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

The polarization of distinct scaffold-signaling hubs at opposite cell poles constitutes the basis of asymmetric cell division. Here, the authors show that phase separation serves as a general mechanism to regulate the assembly and dynamics of a new-pole scaffold-signaling hub.