Objective To investigate the clinical value of intravenous lidocaine in reducing CRBD in male patients who need catheterization after general anesthesia. Methods A total of 210 male patients who underwent elective general anesthesia in our hospital from May 2017 to April 2018 were selected. Random number table method was used to divide into the lidocaine group (1.5 mg • kg-1 of intravenous lidocaine infusion during anesthesia induction, and continuous intravenous infusion of lidocaine 2 mg • kg-1 • h-1 after intubation), Dexmedetomidine group (0.5 μg • kg-1 of dexmedetomidine intravenously during anesthesia induction, continuous intravenous infusion of dexmedetomidine 0.4 μg • kg-1 • h-1 after intubation). Control group (intravenous saline infusion during anesthesia induction, continuous intravenous infusion of the same amount of saline after intubation), 70 cases in each group. All three groups were placed in the bladder with a 16F comfortable urethral catheter lubricated with paraffin oil. The amount of sufentanil used during the operation, the amount of sufentanil used after surgery, and the CRBD score and VAS at different time points after extubation were compared. Scoring, HR, SBP. Results T1 to T4, the CRBD scores of the lidocaine group were lower than those of the dexmedetomidine group and the control group (P 0.05). Conclusion Lidocaine administration in male patients requiring catheterization after general anesthesia can significantly reduce the incidence of CRBD.