Detection of determinant genes and diagnostic via Item Response Theory

Abstract

This work presents a method to analyze characteristics of a set of genes that can have an influence in a certain anomaly, such as a particular type of cancer. A measure is proposed with the objective of diagnosing individuals regarding the anomaly under study and some characteristics of the genes are analyzed. Maximum likelihood equations for general and particular cases are presented.

Keywords

• Item Response Theory (IRT)
• predisposition
• propensity
• logistic model