Nature Communications (Oct 2021)
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
- Myung-Chul Kim,
- Nicholas Borcherding,
- Kawther K. Ahmed,
- Andrew P. Voigt,
- Ajaykumar Vishwakarma,
- Ryan Kolb,
- Paige N. Kluz,
- Gaurav Pandey,
- Umasankar De,
- Theodore Drashansky,
- Eric Y. Helm,
- Xin Zhang,
- Katherine N. Gibson-Corley,
- Julia Klesney-Tait,
- Yuwen Zhu,
- Jinglu Lu,
- Jinsong Lu,
- Xian Huang,
- Hongrui Xiang,
- Jinke Cheng,
- Dongyang Wang,
- Zheng Wang,
- Jian Tang,
- Jiajia Hu,
- Zhengting Wang,
- Hua Liu,
- Mingjia Li,
- Haoyang Zhuang,
- Dorina Avram,
- Daohong Zhou,
- Rhonda Bacher,
- Song Guo Zheng,
- Xuefeng Wu,
- Yousef Zakharia,
- Weizhou Zhang
Affiliations
- Myung-Chul Kim
- Department of Pathology, Immunology and Laboratory Medicine, University of Florida
- Nicholas Borcherding
- Department of Pathology, University of Iowa
- Kawther K. Ahmed
- Department of Pathology, University of Iowa
- Andrew P. Voigt
- Medical Scientist Training Program, University of Iowa
- Ajaykumar Vishwakarma
- Cancer Biology Graduate Program, University of Iowa
- Ryan Kolb
- Department of Pathology, Immunology and Laboratory Medicine, University of Florida
- Paige N. Kluz
- Department of Pathology, University of Iowa
- Gaurav Pandey
- Department of Pathology, University of Iowa
- Umasankar De
- Department of Pathology, Immunology and Laboratory Medicine, University of Florida
- Theodore Drashansky
- Department of Anatomy and Cell Biology, University of Florida College of Medicine, 32610
- Eric Y. Helm
- Department of Anatomy and Cell Biology, University of Florida College of Medicine, 32610
- Xin Zhang
- UF Health Cancer Center, University of Florida
- Katherine N. Gibson-Corley
- Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center
- Julia Klesney-Tait
- Department of Internal Medicine, University of Iowa
- Yuwen Zhu
- Department of Surgery, University of Colorado Anschutz Medical Campus
- Jinglu Lu
- Department of Breast Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
- Jinsong Lu
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
- Xian Huang
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
- Hongrui Xiang
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
- Jinke Cheng
- Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Dongyang Wang
- Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Zheng Wang
- Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Jian Tang
- Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Jiajia Hu
- Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Zhengting Wang
- Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Hua Liu
- Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Mingjia Li
- Department of Medicine, Division of Rheumatology & Clinical Immunology, University of Florida
- Haoyang Zhuang
- Department of Medicine, Division of Rheumatology & Clinical Immunology, University of Florida
- Dorina Avram
- UF Health Cancer Center, University of Florida
- Daohong Zhou
- UF Health Cancer Center, University of Florida
- Rhonda Bacher
- Department of Biostatistics, University of Florida
- Song Guo Zheng
- Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center
- Xuefeng Wu
- Department of Breast Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
- Yousef Zakharia
- Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center
- Weizhou Zhang
- Department of Pathology, Immunology and Laboratory Medicine, University of Florida
- DOI
- https://doi.org/10.1038/s41467-021-26091-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome.
