The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon

Hikaru Eto; Yusuke Kishi; Nayuta Yakushiji-Kaminatsui; Hiroki Sugishita; Shun Utsunomiya; Haruhiko Koseki; Yukiko Gotoh

doi:10.1038/s41467-020-19556-5

Nature Communications (Nov 2020)

The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon

Hikaru Eto,
Yusuke Kishi,
Nayuta Yakushiji-Kaminatsui,
Hiroki Sugishita,
Shun Utsunomiya,
Haruhiko Koseki,
Yukiko Gotoh

Affiliations

Hikaru Eto: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Yusuke Kishi: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Nayuta Yakushiji-Kaminatsui: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS)
Hiroki Sugishita: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS)
Shun Utsunomiya: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Haruhiko Koseki: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS)
Yukiko Gotoh: Graduate School of Pharmaceutical Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-020-19556-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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NCOMMS-19-38235B Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions. Here, the authors find that PcG proteins suppress BMP and Wnt signaling in a region-specific manner, allowing for proper Shh expression and development of the ventral telencephalon.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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