Nature Communications (Mar 2020)
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
- Judith Lang,
- Patrick Bohn,
- Hilal Bhat,
- Holger Jastrow,
- Bernd Walkenfort,
- Feyza Cansiz,
- Julian Fink,
- Michael Bauer,
- Dominik Olszewski,
- Ana Ramos-Nascimento,
- Vikas Duhan,
- Sarah-Kim Friedrich,
- Katrin Anne Becker,
- Adalbert Krawczyk,
- Michael J. Edwards,
- Andreas Burchert,
- Magdalena Huber,
- Justa Friebus-Kardash,
- Joachim R. Göthert,
- Cornelia Hardt,
- Hans Christian Probst,
- Fabian Schumacher,
- Karl Köhrer,
- Burkhard Kleuser,
- Eduard B. Babiychuk,
- Beate Sodeik,
- Jürgen Seibel,
- Urs F. Greber,
- Philipp A. Lang,
- Erich Gulbins,
- Karl S. Lang
Affiliations
- Judith Lang
- Institute of Immunology, University of Duisburg-Essen
- Patrick Bohn
- Institute of Immunology, University of Duisburg-Essen
- Hilal Bhat
- Institute of Immunology, University of Duisburg-Essen
- Holger Jastrow
- Institute of Anatomy, University of Duisburg-Essen
- Bernd Walkenfort
- Institut for Experimental Immunology and Imaging, Imaging Center Essen, Electron Microscopy Unit, University of Duisburg-Essen
- Feyza Cansiz
- Institute of Immunology, University of Duisburg-Essen
- Julian Fink
- Institute of Organic Chemistry, Julius-Maximilians University of Würzburg
- Michael Bauer
- Department of Molecular Life Sciences, University of Zurich
- Dominik Olszewski
- Department of Molecular Life Sciences, University of Zurich
- Ana Ramos-Nascimento
- Institute of Virology, Hannover Medical School
- Vikas Duhan
- Institute of Immunology, University of Duisburg-Essen
- Sarah-Kim Friedrich
- Institute of Immunology, University of Duisburg-Essen
- Katrin Anne Becker
- Institute of Molecular Biology, University of Duisburg-Essen
- Adalbert Krawczyk
- Institute for Virology, University of Duisburg-Essen
- Michael J. Edwards
- Department of Surgery, University of Cincinnati
- Andreas Burchert
- Department of Hematology, Oncology and Immunology, University Hospital Giessen and Marburg, Campus Marburg
- Magdalena Huber
- Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg
- Justa Friebus-Kardash
- Institute of Immunology, University of Duisburg-Essen
- Joachim R. Göthert
- Department of Hematology, West German Cancer Center, University Hospital of Essen, University of Duisburg-Essen
- Cornelia Hardt
- Institute of Immunology, University of Duisburg-Essen
- Hans Christian Probst
- Institute of Immunology, University Medical Center Mainz
- Fabian Schumacher
- Institute of Molecular Biology, University of Duisburg-Essen
- Karl Köhrer
- Biological and Medical Research Center (BMFZ), Heinrich-Heine−University, Universitätsstr. 1
- Burkhard Kleuser
- Institute of Nutritional Science, University of Potsdam
- Eduard B. Babiychuk
- Institute of Anatomy, University of Bern
- Beate Sodeik
- Institute of Virology, Hannover Medical School
- Jürgen Seibel
- Institute of Organic Chemistry, Julius-Maximilians University of Würzburg
- Urs F. Greber
- Department of Molecular Life Sciences, University of Zurich
- Philipp A. Lang
- Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Universitätsstr. 1
- Erich Gulbins
- Institute of Molecular Biology, University of Duisburg-Essen
- Karl S. Lang
- Institute of Immunology, University of Duisburg-Essen
- DOI
- https://doi.org/10.1038/s41467-020-15072-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
