Global genetic differentiation of complex traits shaped by natural selection in humans

Jing Guo; Yang Wu; Zhihong Zhu; Zhili Zheng; Maciej Trzaskowski; Jian Zeng; Matthew R. Robinson; Peter M. Visscher; Jian Yang

doi:10.1038/s41467-018-04191-y

Nature Communications (May 2018)

Global genetic differentiation of complex traits shaped by natural selection in humans

Jing Guo,
Yang Wu,
Zhihong Zhu,
Zhili Zheng,
Maciej Trzaskowski,
Jian Zeng,
Matthew R. Robinson,
Peter M. Visscher,
Jian Yang

Affiliations

Jing Guo: Institute for Molecular Bioscience, The University of Queensland
Yang Wu: Institute for Molecular Bioscience, The University of Queensland
Zhihong Zhu: Institute for Molecular Bioscience, The University of Queensland
Zhili Zheng: Institute for Molecular Bioscience, The University of Queensland
Maciej Trzaskowski: Institute for Molecular Bioscience, The University of Queensland
Jian Zeng: Institute for Molecular Bioscience, The University of Queensland
Matthew R. Robinson: Institute for Molecular Bioscience, The University of Queensland
Peter M. Visscher: Institute for Molecular Bioscience, The University of Queensland
Jian Yang: Institute for Molecular Bioscience, The University of Queensland

DOI: https://doi.org/10.1038/s41467-018-04191-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Human complex traits and disorders often show differentiation among populations. Here, the authors analyze SNPs associated with 10 complex traits using data of large sample size from African, East Asian and European populations, and find significant genetic differentiation among global populations shaped by natural selection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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