Nature Communications (Dec 2019)
Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
- Andreas Marg,
- Helena Escobar,
- Nikos Karaiskos,
- Stefanie A. Grunwald,
- Eric Metzler,
- Janine Kieshauer,
- Sascha Sauer,
- Diana Pasemann,
- Edoardo Malfatti,
- Dominique Mompoint,
- Susanna Quijano-Roy,
- Anastasiya Boltengagen,
- Joanna Schneider,
- Markus Schülke,
- Séverine Kunz,
- Robert Carlier,
- Carmen Birchmeier,
- Helge Amthor,
- Andreas Spuler,
- Christine Kocks,
- Nikolaus Rajewsky,
- Simone Spuler
Affiliations
- Andreas Marg
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Helena Escobar
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Nikos Karaiskos
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Stefanie A. Grunwald
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Eric Metzler
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Janine Kieshauer
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Sascha Sauer
- Berlin Institute of Medical Systems Biology (BIMSB) at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Diana Pasemann
- Department of Nuclear Medicine, Charité Universitätsmedizin Berlin
- Edoardo Malfatti
- INSERM U1179, Université de Versailles Saint-Quentin-en-Yvelines
- Dominique Mompoint
- INSERM U1179, Université de Versailles Saint-Quentin-en-Yvelines
- Susanna Quijano-Roy
- INSERM U1179, Université de Versailles Saint-Quentin-en-Yvelines
- Anastasiya Boltengagen
- Berlin Institute of Medical Systems Biology (BIMSB) at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Joanna Schneider
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Markus Schülke
- Department of Neuropediatrics, Charité Universitätsmedizin Berlin
- Séverine Kunz
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Robert Carlier
- INSERM U1179, Université de Versailles Saint-Quentin-en-Yvelines
- Carmen Birchmeier
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Helge Amthor
- INSERM U1179, Université de Versailles Saint-Quentin-en-Yvelines
- Andreas Spuler
- Department of Neurosurgery, HELIOS Klinikum Berlin-Buch
- Christine Kocks
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Nikolaus Rajewsky
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- Simone Spuler
- Muscle Research Unit, Experimental and Clinical Research Center, a joint cooperation of Charité, Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
- DOI
- https://doi.org/10.1038/s41467-019-13650-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and contribute to the muscle stem cell niche when transplanted into mice.
