Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

S. R. Rosario; M. D. Long; H. C. Affronti; A. M. Rowsam; K. H. Eng; D. J. Smiraglia

doi:10.1038/s41467-018-07232-8

Nature Communications (Dec 2018)

Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

S. R. Rosario,
M. D. Long,
H. C. Affronti,
A. M. Rowsam,
K. H. Eng,
D. J. Smiraglia

Affiliations

S. R. Rosario: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute
M. D. Long: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute
H. C. Affronti: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute
A. M. Rowsam: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute
K. H. Eng: Department of Biostatistics, Roswell Park Cancer Institute
D. J. Smiraglia: Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute

DOI: https://doi.org/10.1038/s41467-018-07232-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

Read online

Metabolism is frequently dysregulated in cancer. Here, the authors conduct a pan-cancer analysis of The Cancer Genome Atlas to determine significant metabolic pathway alterations, highlight master metabolic transcriptional regulators, and predict patient response to metabolism targeted-therapeutics

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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