A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

Justin Rebo; Melod Mehdipour; Ranveer Gathwala; Keith Causey; Yan Liu; Michael J. Conboy; Irina M. Conboy

doi:10.1038/ncomms13363

Nature Communications (Nov 2016)

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

Justin Rebo,
Melod Mehdipour,
Ranveer Gathwala,
Keith Causey,
Yan Liu,
Michael J. Conboy,
Irina M. Conboy

Affiliations

Justin Rebo: Department of Bioengineering and QB3 Institute, 174 Stanley Hall, University of California, Berkeley, Berkeley, California 94720-3220, USA
Melod Mehdipour: Department of Bioengineering and QB3 Institute, 174 Stanley Hall, University of California, Berkeley, Berkeley, California 94720-3220, USA
Ranveer Gathwala: Department of Bioengineering and QB3 Institute, 174 Stanley Hall, University of California, Berkeley, Berkeley, California 94720-3220, USA
Keith Causey: SENS Research Foundation, 110 Pioneer Way, Suite J
Yan Liu: Department of Bioengineering and QB3 Institute, 174 Stanley Hall, University of California, Berkeley, Berkeley, California 94720-3220, USA
Michael J. Conboy: Department of Bioengineering and QB3 Institute, 174 Stanley Hall, University of California, Berkeley, Berkeley, California 94720-3220, USA
Irina M. Conboy: Department of Bioengineering and QB3 Institute, 174 Stanley Hall, University of California, Berkeley, Berkeley, California 94720-3220, USA

DOI: https://doi.org/10.1038/ncomms13363
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

Read online

Joining the circulatory system of an old with a young animal has been shown to rejuvenate old tissues. Here the authors describe a comparatively simple blood infusion system that allows for the controlled exchange of blood between two animals, and study the effects of a single exchange on various tissues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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