Histone H3 variants at the root of metastasis

Abstract

Chromatin remodeling is at the root of any cell fate decision, laying the foundation for the necessary reprogramming to occur. Our work shows histone H3 variants as a new addition to the ever-growing body of epigenetic regulators, one that is essential for cell fate transitions in carcinoma cells to promote tumor progression and metastasis.

Keywords

• tumor progression
• metastasis
• epigenetics
• histone h3.3
• histone chaperones