Acta Crystallographica Section E (Apr 2013)

Ethyl 23-benzyl-8,11,14-trioxa-23,28,29-triazapentacyclo[19.7.1.02,7.015,20.022,27]nonacosa-2,4,6,15(20),16,18,21,26-octaene-26-carboxylate

  • Truong Hong Hieu,
  • Le Tuan Anh,
  • Anatoly T. Soldatenkov,
  • Vasily G. Vasil'ev,
  • Victor N. Khrustalev

DOI
https://doi.org/10.1107/S1600536813007241
Journal volume & issue
Vol. 69, no. 4
pp. o565 – o566

Abstract

Read online

The title compound, C33H35N3O5, is the product of the multicomponent condensation of 1-benzyl-4-ethoxycarbonylpiperidin-3-one with 1,5-bis(2-formylphenoxy)-3-oxapentane and ammonium acetate. The molecule comprises a pentacyclic system containing the aza-14-crown-4-ether macrocycle, tetrahydropyrimidine, tetrahydropyridine and two benzene rings. The aza-14-crown-4-ether ring adopts a bowl conformation with a dihedral angle of 62.37 (5)° between the benzene rings. The tetrahydropyrimidine ring has an envelope conformation with the chiral C atom as the flap, whereas the tetrahydropyridine ring adopts a distorted chair conformation. Two amino groups are involved in intramolecular N—H...O hydrogen bonds. In the crystal, weak C—H...O hydrogen bonds link the molecules into layers parallel to the ab plane.