Experimental Hematology & Oncology (Nov 2017)

Development and clinical application of anti-HER2 monoclonal and bispecific antibodies for cancer treatment

  • Shengnan Yu,
  • Qian Liu,
  • Xinwei Han,
  • Shuang Qin,
  • Weiheng Zhao,
  • Anping Li,
  • Kongming Wu

DOI
https://doi.org/10.1186/s40164-017-0091-4
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 15

Abstract

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Abstract HER2-targeted immunotherapy consists of monoclonal antibodies (e.g. trastuzumab, pertuzumab), bispecific antibodies (e.g. MM-111, ertumaxomab) and activated T cells armed with anti-HER2 bispecific antibody (HER2Bi-aATC). Trastuzumab is a classic drug for the treatment of HER2 positive metastatic breast cancer. The combined application of pertuzumab, trastuzumab and paclitaxel has been suggested as a standard therapy for HER2 positive advanced breast cancer. The resistance to anti-HER2 antibody has resulted in disease progression. HER2-directed bispecific antibody may be a promising therapeutic approach for these patients. Ertumaxomab enhanced the interaction of immune effector cells and tumor cells. MM-111 simultaneously binds to HER2 and HER3 and blocks downstream signaling. Besides, HER2Bi-aATC is also an alternative therapeutic approach for HER2 positive cancers. In this review, we summarized the recent advancement of HER2-targeted monoclonal antibodies (trastuzumab, pertuzumab and T-DM1) and bispecific antibodies (MM-111, ertumaxomab and HER2Bi-aATC), especially focus on clinical trial results.

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