Nature Communications (Jan 2021)

Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity

  • Kevin C. H. Ha,
  • Timothy Sterne-Weiler,
  • Quaid Morris,
  • Robert J. Weatheritt,
  • Benjamin J. Blencowe

DOI
https://doi.org/10.1038/s41467-020-20483-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Post-transcriptional gene regulation is an important contributor to cell type-specific differences at the transcriptomic level. Here, the authors use a multiomics approach to characterize neuronal diversity in the mouse nervous system, analyzing the relative contributions of multiple layers of transcriptomic regulation in the specification of cell type identity.