Data characterizing the ZMIZ1 molecular phenotype of multiple sclerosis
N. Fewings,
P.N. Gatt,
F.C. McKay,
G.P. Parnell,
S.D. Schibeci,
J. Edwards,
M.A. Basuki,
A. Goldinger,
M.J. Fabis-Pedrini,
A.G. Kermode,
C.P. Manrique,
J.L. McCauley,
D. Nickles,
S.E. Baranzini,
T. Burke,
S. Vucic,
G.J. Stewart,
D.R. Booth
Affiliations
N. Fewings
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
P.N. Gatt
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
F.C. McKay
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
G.P. Parnell
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
S.D. Schibeci
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
J. Edwards
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
M.A. Basuki
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
A. Goldinger
University of Queensland Diamantina Institute, Translational Research Institute, Australia
M.J. Fabis-Pedrini
Western Australian Neuroscience Research Institute, University of Western Australia, Nedlands, Western Australia, Australia
A.G. Kermode
Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
C.P. Manrique
John P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
J.L. McCauley
John P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
D. Nickles
Department of Neurology, University of California San Francisco, USA
S.E. Baranzini
Department of Neurology, University of California San Francisco, USA
T. Burke
Western Clinical School, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia
S. Vucic
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
G.J. Stewart
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
D.R. Booth
Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
The data presented in this article are related to the research article entitled “The autoimmune risk gene ZMIZ1 is a vitamin D responsived marker of a molecular phenotype of multiple sclerosis” Fewings et al. (2017) [1]. Here we identify the set of genes correlated with ZMIZ1 in multiple cohorts, provide phenotypic details on those cohorts, and identify the genes negatively correlated with ZMIZ1 and the cells predominantly expressing those genes. We identify the metabolic pathways in which the molecular phenotype genes are over-represented. Finally, we present the flow cytometry gating strategy we have used to identify the immune cells from blood which are producing ZMIZ1 and RPS6.
