Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Jan 2020)
Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)
- Roxana O. Carare,
- Roxana Aldea,
- Nivedita Agarwal,
- Brian J. Bacskai,
- Ingo Bechman,
- Delphine Boche,
- Guojun Bu,
- Diederik Bulters,
- Alt Clemens,
- Scott E. Counts,
- Mony deLeon,
- Per K. Eide,
- Silvia Fossati,
- Steven M. Greenberg,
- Edith Hamel,
- Cheryl A. Hawkes,
- Maya Koronyo‐Hamaoui,
- Atticus H. Hainsworth,
- David Holtzman,
- Masafumi Ihara,
- Angela Jefferson,
- Raj N. Kalaria,
- Christopher M. Kipps,
- Katja M. Kanninen,
- Ville Leinonen,
- JoAnne McLaurin,
- Scott Miners,
- Tarja Malm,
- James A. R. Nicoll,
- Fabrizio Piazza,
- Gesine Paul,
- Steven M. Rich,
- Satoshi Saito,
- Andy Shih,
- Henrieta Scholtzova,
- Heather Snyder,
- Peter Snyder,
- Finnbogi Rutur Thormodsson,
- Susanne J. vanVeluw,
- Roy O. Weller,
- David J. Werring,
- Donna Wilcock,
- Mark R. Wilson,
- Berislav V. Zlokovic,
- Ajay Verma
Affiliations
- Roxana O. Carare
- University of Southampton Southampton UK
- Roxana Aldea
- Roche Innovation Center Basel Basel Switzerland
- Nivedita Agarwal
- Hospital Santa Maria del Carmine Rovereto Italy
- Brian J. Bacskai
- Harvard University Cambridge Massachusetts USA
- Ingo Bechman
- University of Leipzig Leipzig Germany
- Delphine Boche
- University of Southampton Southampton UK
- Guojun Bu
- Mayo Clinic Jacksonville Florida USA
- Diederik Bulters
- University of Southampton Southampton UK
- Alt Clemens
- Harvard University Cambridge Massachusetts USA
- Scott E. Counts
- Michigan State University East Lansing Michigan USA
- Mony deLeon
- Weill Cornell Medicine New York USA
- Per K. Eide
- University of Oslo Oslo Norway
- Silvia Fossati
- Temple University Philadelphia Pennsylvania USA
- Steven M. Greenberg
- Harvard University Cambridge Massachusetts USA
- Edith Hamel
- McGill University Montreal Canada
- Cheryl A. Hawkes
- University of Lancaster Lancashire UK
- Maya Koronyo‐Hamaoui
- Cedars‐Sinai Medical Center Los Angeles California USA
- Atticus H. Hainsworth
- St George's University of London London UK
- David Holtzman
- Washington University St Louis St. Louis Missouri USA
- Masafumi Ihara
- National Cerebral and Cardiovascular Center Osaka Japan
- Angela Jefferson
- Vanderbilt University Nashville Tennessee USA
- Raj N. Kalaria
- Newcastle University Tyne UK
- Christopher M. Kipps
- University of Southampton Southampton UK
- Katja M. Kanninen
- University of Eastern Finland Kuopio Finland
- Ville Leinonen
- University of Eastern Finland Kuopio Finland
- JoAnne McLaurin
- Sunnybrook Research Institute Toronto Ontario Canada
- Scott Miners
- Bristol University Bristol UK
- Tarja Malm
- University of Eastern Finland Kuopio Finland
- James A. R. Nicoll
- University of Southampton Southampton UK
- Fabrizio Piazza
- University of Milano ‐ Bicocca Monza Italy
- Gesine Paul
- Lund University Lund Sweden
- Steven M. Rich
- QAAM Pharmaceuticals LLC Canandaigua New York USA
- Satoshi Saito
- National Cerebral and Cardiovascular Center Osaka Japan
- Andy Shih
- Seattle Children's Hospital Seattle Washington USA
- Henrieta Scholtzova
- New York University New York New York USA
- Heather Snyder
- Alzheimer's Association Chicago Illinois USA
- Peter Snyder
- University of Rhode Island South Kingstown Rhode Island USA
- Finnbogi Rutur Thormodsson
- University of Akureyri Akureyri Iceland
- Susanne J. vanVeluw
- Harvard University Cambridge Massachusetts USA
- Roy O. Weller
- University of Southampton Southampton UK
- David J. Werring
- Stroke Research Centre UCL Queen Square Institute of Neurology University College London London UK
- Donna Wilcock
- University of Kentucky Lexington Kentucky USA
- Mark R. Wilson
- University of Wollongong Wollongong Australia
- Berislav V. Zlokovic
- University of Southern California Los Angeles California USA
- Ajay Verma
- CODIAK Biosciences Cambridge Massachusetts USA
- DOI
- https://doi.org/10.1002/dad2.12053
- Journal volume & issue
-
Vol. 12,
no. 1
pp. n/a – n/a
Abstract
Abstract Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri‐arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.
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