Thyroid pathology in patients with acromegaly: review of literature and own researches

Abstract

The analysis of medical scientific literature and retrospective analysis were performed using medical documents of patients treated in the cliniс of the State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, in order to study a thyroid pathology in acromegalic patients. In accordance with data of international studies, the multinodular goiter constitutes the biggest part in the structure of thyroid pathology of acromegalic patients, and the incidence of thyroid cancer ranges from 3 to 12.5 %. Among acromegalic patients who were treated in this clinic, the thyroid pathology was observed in 97.7 % of patients, and the part of multinodular goiter made up 51.2 %, autoimmune thyroiditis — 13.9 %, thyroid cancer — 4.6 %. It may be concluded that it is necessary to evaluate on a constant basis the condition of thyroid gland in acromegalic patients for timely diagnosis and treatment, especially in terms of thyroid cancer risk.

Keywords

• acromegaly
• multinodular goiter
• thyroid cancer