Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model
Tycho Baumann,
Julio Delgado,
Rodrigo Santacruz,
Alejandra Martínez-Trillos,
Cristina Royo,
Alba Navarro,
Magda Pinyol,
María Rozman,
Arturo Pereira,
Neus Villamor,
Marta Aymerich,
Cristina López,
Anna Carrió,
Emili Montserrat
Affiliations
Tycho Baumann
Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain;Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Julio Delgado
Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain
Rodrigo Santacruz
Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain
Alejandra Martínez-Trillos
Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain;Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Cristina Royo
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Alba Navarro
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Magda Pinyol
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
María Rozman
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Arturo Pereira
Department of Hemotherapy and Hemostasis; and Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Neus Villamor
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Marta Aymerich
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Cristina López
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Anna Carrió
Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Emili Montserrat
Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain
We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P
