International Journal of Molecular Sciences (Apr 2012)
Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes
Abstract
A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX<sub>2</sub>] (where L = N<sub>4</sub> donor macrocyclic ligands) and (X = Cl<sup>−</sup>, NO<sub>3</sub><sup>−</sup>) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl<sub>2</sub> and [Cu(DBACDT)](NO<sub>3</sub>)<sub>2</sub> complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.
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